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The Best 6 Supplements For Muscle Gain

The Best 6 Supplements For Muscle Gain
Claire Muszalski
Writer and expert3 years ago
View Claire Muszalski's profile

Building muscle can often be hard. Everyone knows somebody who just has to look at the squat rack to pack on the muscle, but for those not as genetically gifted, getting your muscle building supplement strategy right can really help. 

If you want to make the most of your training sessions, then knowing how your body builds muscle, and which performance-enhancing supplements can support your specific goals is incredibly valuable. Our list of the 6 best supplements for muscle gain, below, will help you to select the perfect choice for you. 

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Best Supplements for Muscle Gain

1. Whey Protein

Whey protein has a particularly fast digestion rate, which means the amino acids contained in a whey protein powder will be available to build muscle shortly after youve consumed it.10 When you consume a protein source, the protein is digested and the amino acids enter the bloodstream. The faster the protein is digested, the faster the amino acids are available for use to build new muscle.10

Whey also has a high leucine content, which is needed to switch on your body’s muscle protein synthesis processes (your body’s ability to use protein for muscle growth).11

Due to its fast digestion rate and amino acid content, having a whey protein shake following resistance training further enhances the effect on muscle growth in comparison to following up training without whey protein powder.12Whey is considered the best protein for muscle gain thanks to its amino acid profile and fast absorption rate.


2. Casein Protein

Casein is a protein found in milk and other dairy products. Due to its slow digestion rate, it’s been shown to prolong increased muscle protein synthesis (MPS) compared to whey protein.10 

It’s also been shown to reduce muscle protein breakdown, which is when muscle protein is broken down and used for energy.13 This is important as it’ll help your body to preserve the positive muscle protein turnover required for muscle gain. 

Because of all this, casein has been touted as the best protein to have pre-bedtime, as it’ll maintain increased protein synthesis even whilst you sleep.14 Sleep is the best natural recovery for our bodies, so adding casein into the mix makes it all the more beneficial.


3. Protein Blends

Protein blends are shakes which contain both whey and casein and aim to give you the best of both worlds. Whey protein will provide the initial high spike in muscle protein synthesis and the casein will help to prolong this increased rate of synthesis.15

In a study that looked at 10 weeks of resistance training, those who used a protein blend of casein and whey built more muscle than those only using whey protein.16

While whey and casein have impressive amino acid profiles, you can also get all of the necessary amino acids using a vegan protein blend. While individual vegan proteins might not have all of the essential amino acids, using a vegan protein blend can be just as effective at providing all of necessary amino acids for muscle gain.


4. Creatine

Creatine is considered one of the best supplements for muscle gain, and for good reason.1 The evidence suggests that creatine supplementation can help you gain nearly twice as much muscle mass than if you didn’t use it.17

The exact mechanisms for the increase in muscle mass are unclear when using creatine, however, it’s speculated that these gains may be due to an increased capacity to perform a larger amount of high-quality training.17

Creatine works by making ATP (energy) readily available for muscle contraction. When there is more ATP available, your muscles can perform at a high level by increasing the number of reps and power during anaerobic exercise (like lifting or HIIT training).  

With full creatine stores, youll be able to push out extra reps and improve recovery between sets. Want more info? Watch this next.


5. BCAAs

BCAAs, also known as branch-chained amino acids, contain leucine, which acts as a ‘trigger’ to enhance muscle protein synthesis rates.11 Using BCAAs can be preferred to other protein sources when you’re in a caloric deficit, as they are typically low in sugar, carbs, and fat, but just provide the most important protein building blocks for your muscles. BCAAs are one of the best supplements for cutting. 

BCAAs have also been shown to ‘rescue’ a meal low in protein and provide a similar increase in muscle protein synthesis rates if taken alongside a meal low in protein.18 

This makes BCAAs a great option for those looking to gain muscle whilst following a vegetarian or vegan diet.

Want more info on BCAAs? Check out this video.


6. HMB

HMB, also known as beta-hydroxy-beta-methylbutyrate, is naturally produced in the body following leucine consumption. Supplementing HMB alongside resistance training has been shown to increase muscle between 0.5kg and 1kg during 3-6 weeks of training.2

The current consensus is that HMB speeds up the muscle regeneration process following high-intensity and long-duration training and, like casein, helps to reduce muscle protein breakdown.2

The effects appear to be more pronounced in those with less training experience. This is due to it taking less training to damage the muscle tissue in a way that will be noticeable with HMB supplementation.2 

The most optimal way to take HMB would be a dosage of 1.5-3g daily.2


How do you build muscle?

In order to build muscle, you need to be in a positive protein balance, and that’s where protein powder can help. In your body, there’s a continuous muscle protein turnover, with periods of increased muscle protein synthesis (where muscle is built) and periods of muscle protein breakdown (where muscle is broken down for energy). 

If your total muscle protein synthesis exceeds muscle protein breakdown, then you’ll gain muscle mass. On the flip side, if MPB exceeds MPS, the overall result will be a loss of muscle. 

You can easily increase your MPS rates if you have a high-protein diet, or perform resistance training, with a combination of both being the most effective.1

Still not sure? Watch our expert nutritionist explain more.


Should I just eat protein for building muscle?

Whilst protein can assist muscle growth, there are other supplements and nutrients, which can also aid this process. Macronutrients are especially important:



Eating a protein source that’s rich in amino acids will increase your body’s rate of muscle protein synthesis both at rest and after exercise.1

The evidence shows that, when combined with resistance training, a daily intake of 1.4g of protein per kilogram of bodyweight per day to 1.8g/kg/d will be enough to build muscle.2

If you’re looking to lose body fat and build muscle, then that intake may need to be increased. Recent studies have shown that you can still build muscle even in a negative energy balance, providing your protein intake is high enough.3

In a recent study comparing 1.2g/kg/d to 2.4g/kg/d, the higher intake was more successful at building muscle mass than the lower intake.3

So really, if you’re in an energy deficit, you should aim to get in 2.4g/kg/d in order to enhance the likelihood of muscle gain. Protein supplements are ideal to help you achieve this target. Although it is possible to meet your protein goals through whole foods, using a supplement is an efficient way to target just your protein intake.

Looking for some high protein recipes? Start with these 3 high-protein breakfasts... 



Evidence shows that combining protein with carbohydrates can accelerate muscle protein synthesis rates more than protein alone.4

Carbohydrate intake will also increase your glycogen storage. Carbohydrates are stored in the body as glycogen to be used for energy. This is important as any workout requires glycogen as fuel.5 Studies show that, during resistance training, glycogen can be depleted by as much as 40%.5

So, carbohydrates are super beneficial to recovery and boost muscle protein synthesis rates. 

For those training with high volume, such as body builders, an intake as high as 5-6g/kg/d of carbohydrates has been recommended.7

Want to know more about how carbs can benefit you?



When it comes to fat intake and muscle gain, the data is inconclusive.7 However, low fat diets have been shown to reduce testosterone levels, which may affect the amount of muscle gained.8

There’s also some evidence to suggest that omega-3 supplementation can help boost muscle protein synthesis, as it makes muscle cells more sensitive to amino acids. However, the evidence is a little contradictory. The present view is that, when you’ve consumed enough protein, the effect of omega-3 supplementation on MPS is negligible. However, if you can’t get enough protein in, then omega-3 supplementation may help.9

Fats also have a lot of other benefits to our health, learn more about fat here.


Take home message

The best way to achieve muscle growth is with a combination of resistance training, adequate protein intake, plenty of carbohydrates and healthy fats. All of these will aid recovery and help you to keep training at the right intensity to help build that muscle.

Supplements like protein shakes help to get you those nutrients quickly and conveniently to give you the best chance at making sure all your hard work in the gym pays off.


Our articles should be used for informational and educational purposes only and are not intended to be taken as medical advice. If you're concerned, consult a health professional before taking dietary supplements or introducing any major changes to your diet.

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9. Rossato, L., Schoenfeld, B. and de Oliveira, E. (2019). Is there sufficient evidence to supplement omega-3 fatty acids to increase muscle mass and strength in young and older adults?. Clinical Nutrition. In Press.

10. Boirie Y, Dangin M, Gachon P, Vasson MP, Maubois JL, Beaufre`re B (1997). Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci 94:14930–14935, 1997.

11. Wilkinson DJHossain THill DSPhillips BECrossland HWilliams J,… Atherton PJ. (2013). Effects of leucine and its metabolite B-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism. J Physiol 2013. 1;591(11):2911-23

12. Cintineo, H., Arent, M., Antonio, J. and Arent, S. (2018). Effects of Protein Supplementation on Performance and Recovery in Resistance and Endurance Training. Frontiers in Nutrition, 5.

13. Tang JE, Moore DR, Kujbida GW, Tarnopolsky MA, Phillips SM. (2009). Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J Appl Physiol Sep;107(3):987-92.

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Claire Muszalski
Writer and expert
View Claire Muszalski's profile

Claire is a Registered Dietitian through the Academy of Nutrition and Dietetics and a board-certified Health and Wellness Coach through the International Consortium for Health and Wellness Coaching. She has a Bachelor of Science in Biology and a Master’s degree in Clinical Dietetics and Nutrition from the University of Pittsburgh.

Talking and writing about food and fitness is at the heart of Claire’s ethos as she loves to use her experience to help others meet their health and wellness goals.

Claire is also a certified indoor cycling instructor and loves the mental and physical boost she gets from regular runs and yoga classes. When she’s not keeping fit herself, she’s cheering on her hometown’s sports teams in Pittsburgh, or cooking for her family in the kitchen.

Find out more about Claire’s experience here.